Bioterrorism is defined as “the intentional release or threat of release of biologic agents—viruses, bacteria, fungi, or their toxins—to cause disease or death in humans, animals, or crops.” Bioterrorism remains a significant and evolving threat to public [....] » Read More
The Immunization Agenda 2030 (IA2030) proposed by the 73rd World Health Assembly in 2020 committed to eliminating measles in at least five of the six WHO regions by 2030. Mean percentages of vaccination coverage with two, one and zero doses of measles vaccine in WHO regions in 20 [....] » Read More
Background: Japan’s remote island communities face overlapping structural challenges, including rapid population aging, shortages of healthcare professionals, and limited medical resources, making the establishment of sustainable healthcare delivery systems an urgent priori [....] » Read More
Background: Despite national progress towards the elimination of new infections, Tuberculosis (TB) remains a significant public health concern in Northern Saskatchewan (NS), Canada, disproportionately affecting Indigenous populations. The transmission dynamics and genetic strains [....] » Read More
Background: Deployment of effective vaccination against the various SARS-CoV-2 variants was crucial for controlling the spread of COVID-19. These retrospective modelling analyses evaluated the impact of the expanded adolescent COVID-19 vaccination in England at two different [....] » Read More
Co-infection studies indicate that primary influenza infection promotes pneumococcal virulence by causing capillary leakage of nutrients into the lower respiratory tract. This study investigates whether limiting the availability or uptake of auxotrophic B-vitamins can mitigate th [....] » Read More
Introduction/Background: Toxoplasmosis of the central nervous system (CNS) ranks third among the most prevalent opportunistic infections defining AIDS in Brazil, with the brain being the most frequently affected site. Toxoplasma gondii myelitis is considered rare, even in immunos [....] » Read More
Introduction: Invasive fungal infection caused by fungi of the Mucorales order is particularly associated with states of immunocompromise and clinical conditions characterized by hyperglycemia and acidosis. During the SARS-CoV-2 pandemic, an increased prevalence of hyperglyc [....] » Read More
The COVID-19 pandemic exposed significant gaps in the clinical, ethical, and legal frameworks guiding healthcare professionals during epidemiological crises. In Mexico, while numerous guidelines and protocols were rapidly issued, ranging from clinical treatment recommendations to [....] » Read More
Background: Pakistan ranks 6th globally in antibiotic consumption, with patients frequently obtaining medications directly from community pharmacies. Our objective was to evaluate the medicine distribution behaviors of pharmacies for assumed and confirmed tuberculosis utilizing t [....] » Read More
Background: Pakistan is a high-burden country for tuberculosis patients, and medicines and fluoroquinolones hinder diagnosis. The available literature largely uses knowledge surveys and prescription or medical record analysis to assess healthcare practitioners' knowledge [....] » Read More
Introduction: Three patients who underwent angioplasty procedure at a cardiac tertiary care hospital between 29th December 2024 to 30th January 2025, developed high-grade fever with chills within 12 hours of the procedure. Blood culture from these patients yielded growth of pan-s [....] » Read More
Plasmodium falciparum malaria infects 300-500 million individuals and accounts for over 600,000 deaths each year with the majority of deaths occurring in children under 5 years of age living in sub-Saharan Africa. In the past several years, morbidity and mortality due to&nbs [....] » Read More
Background: Rotavirus remains a leading cause of severe childhood diarrhoea, contributing significantly to under-five morbidity and mortality worldwide. In August 2022, Nigeria introduced the rotavirus vaccine into its national immunization program. Continuous surveillance of cir [....] » Read More
Kawasaki Disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) share overlapping clinical features but differ markedly in severity and cardiac outcomes. Both conditions are characterized by systemic hyperinflammation, yet the cellular and metabolic mechanisms dri [....] » Read More
Introduction: Sex differences have been observed in both the incidence and symptom burden of long COVID (LC), with women demonstrating a higher incidence than men (8.5% vs. 5.2%) and greater symptom burden (4.4% vs. 2.3%). Menopause is marked by declining estrogen levels, increas [....] » Read More
Background: Optimising models of care for hepatitis B treatment delivery is an important component of global hepatitis elimination strategies. However, centralised dispensing may increase travel and financial burden for patients, particularly in rural populations. Methods: A r [....] » Read More
Suboptimal immunization coverage remains a major public health concern in middle-income countries, particularly in decentralized health systems. Recent measles outbreaks in the Federation of Bosnia and Herzegovina (FBiH) highlight critical gaps in service delivery and continuity [....] » Read More
A 71-year-old man was admitted to our Department due to hematuria. From his medical history he reported multiple ischemic strokes in the setting of atrial fibrillation, a pacemaker due to complete atrioventricular block and diabetes mellitus on insulin. From the cl [....] » Read More
Introduction: Pediatric urinary tract infections (UTIs) represent an important reservoir of antimicrobial- resistant pathogens, predominantly Escherichia coli, with limited regional data on susceptibility patterns and factors associated with resistance. Antimicrobial resistance [....] » Read More
Sequencing technologies implemented across frontline and public healthcare settings were crucial in developing virus surveillance programs during the coronavirus disease 2019 (COVID19) pandemic caused by the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-Co [....] » Read More
Introduction: Malaria continues to be one of the most significant infectious diseases globally. Its existence in various species complicates the development of an efficient broad-spectrum solution. One species that is gaining increased attention in Southeast Asia is Plasmodium kn [....] » Read More
Decoy Therapeutics is a biotech company pioneering Designable Multi-Antivirals (D-MAVs™) to redefine how viral disease is treated and understood. By harnessing our proprietary IMP³ACT platform, which integrates AI-enabled design with rapid synthesis, we develop adaptab [....] » Read More
Epstein–Barr virus infection and Human Leukocyte Antigen Class II allele DRB1*1501 increase the risk of developing multiple sclerosis, an autoimmune disease of the central nervous system. Human endogenous retroviral envelope proteins, molecular mimicry and neuroinflammation [....] » Read More
Background: In patients with pneumococcal meningoencephalitis, neurological worsening is often reflexively labeled as ischemic stroke or failure of antimicrobial therapy. However, apparent clinical recovery can be deceptive. A hidden immune-mediated phase may emerge after infecti [....] » Read More
Background: Human Immunodeficiency Virus (HIV) remains a global health burden despite advances in antiretroviral therapy (ART). Challenges with daily adherence and multidrug resistance (MDR) necessitate novel approaches. Lenacapavir, a long-acting HIV-1 capsid inhibitor admi [....] » Read More
Background: In patients with pneumococcal meningoencephalitis, neurological worsening is often reflexively labeled as ischemic stroke or failure of antimicrobial therapy. However, apparent clinical recovery can be deceptive. A hidden immune-mediated phase may emerge after infecti [....] » Read More
Background: Orthostatic hypotension is commonly attributed to volume depletion, medication effect, cardiac disease or endocrine dysfunction. However, persistent orthostatic hypotension after correction of reversible causes should prompt consideration of cardiovascular autonomic f [....] » Read More
The protective efficacy of a novel trivalent inactivated Salmonella bacterial vaccine against Salmonella Infantis infection was evaluated in Hy-Line Brown layers. Forty layers were randomly divided into three groups (A to C), with Group B mock-vaccinated with sterile PBS (IM) and [....] » Read More
Background: Sickle cell disease (SCD) is a hereditary hemoglobinopathy typically presenting in early childhood. However, individuals with higher fetal hemoglobin (HbF) levels may exhibit a milder phenotype, delaying recognition until adulthood. Co-infections, such as dengu [....] » Read More
Pulmonary cryptococcosis in immunocompetent individuals represents an underestimated diagnostic and therapeutic challenge, with growing relevance in clinical practice and global public health. Although historically associated with advanced immunosuppression—particularly HIV [....] » Read More
Histoplasmosis is a systemic mycosis of worldwide distribution caused by the inhalation of Histoplasma capsulatum spores. It is characterized by wide clinical variability depending on the fungal load, the patient's immunological status and the virulence of the germ. Object [....] » Read More
Introduction: Infected pseudoaneurysms, though rare, are serious complications arising from septic emboli and pose significant diagnostic and management challenges. The common iliac artery is an unusual site for such aneurysms, accounting for only 2-6% of documented cases. This r [....] » Read More
Background: Streptococcus dysgalactiae (SD) is an uncommon human pathogen and its invasive course and clinical outcomes remain unknown. Bacteremia due to SD with systemic complications is rare with an incidence rate of 7/100,000, and survival in such cases is even rarer. Here, we [....] » Read More
Background: Acinetobacter baumannii is a multidrug-resistant pathogen causing severe ICU-acquired infections with high morbidity and mortality. Identifying local risk factors is essential for targeted infection prevention and control. Objective: To identify clinical and proced [....] » Read More
Tuberculosis (TB) remains the leading cause of death from a bacterial pathogen worldwide, and the limited efficacy of the century-old Mycobacterium bovis Bacillus Calmette–Guérin (BCG) vaccine underscores the urgent need for novel, rationally designed vaccines capabl [....] » Read More
Background: Tuberculosis is a recognized complication associated with the use of biologic therapies for the treatment of autoimmune diseases. The risk of tuberculosis among treated patients may be further increased in tuberculosis-endemic settings such as Colombia. Objective: [....] » Read More
Objective: To examine the equity and inequity inherent in wastewater surveillance systems under different design specifications, using New York State as a case study. Methods: In addition to evaluating the equity of inclusion, we introduce two novel measures of equity in infec [....] » Read More
Background: Influenza vaccination is an effective measure for preventing influenza and its complications, yet vaccine uptake among children remains low in many parts of China, particularly in low-resource settings. Evidence on how multilevel school-based intervention strategies c [....] » Read More
Background : Patients receiving immunosuppressive therapy for B-Cell cancers such as lymphoma and leukemia, may be at an increased risk for reactivation of Hepatitis B infections. Immune Checkpoint Inhibitors,(ICIs), weakens immune responses that control latent viruses. Reactivat [....] » Read More
The purpose of this submission is to present a case report of a patient with disseminated nocardiosis and myasthenia gravis. A 69-year-old male patient presented to the Emergency Department of our hospital with a several-day history of right upper leg swelling and tenderness. [....] » Read More
Background: Antimicrobial resistance (AMR) is recognised as one of the top ten global public health threat by World health organisation. Inappropriate and misuse of antibiotics play a major role in the emergence of multidrug resistant organisms which ultimately leads to trea [....] » Read More
Antibiotic resistance is a complex problem with many interwoven concepts, spanning from individual drug-to-gene interactions to entire gene clusters working in tandem to evade antibiotics. The Comprehensive Antibiotic Resistance Database (CARD) represents individual antimicrobial [....] » Read More
Background : Patients receiving immunosuppressive therapy for B-Cell cancers such as lymphoma and leukemia, may be at an increased risk for reactivation of Hepatitis B infections. Immune Checkpoint Inhibitors,(ICIs), weakens immune responses that control latent viruses. Reactivat [....] » Read More
Introduction: Four-valve endocarditis is exceedingly rare, typically bacterial in origin, and associated with high morbidity and mortality. To our knowledge, we report the first case of quadruple-valve endocarditis caused by Candida parapsilosis. Case Presentation: A 38-year-o [....] » Read More
Introduction: The complicated parapneumonic pleural effusion (CPPE), or empyema, stands for an important pneumonia’s complication in pediatric population, being associated to higher hospitalization and the need to surgical approach. Current medical literature describes high [....] » Read More
Introduction: The complicated parapneumonic pleural effusion (CPPE), or empyema, stands for an important pneumonia’s complication, being associated to higher morbimortality, hospitalization and the frequent need to surgical approach. This article’s goal was to describ [....] » Read More
Personalized and Precision Medicine (PPM).is being the Grand Challenge to forecast, to pre-dict and to prevent is rooted in a big and a new SCIENCE generated by the achievements of (i) Systems & Synthetic Biology; (ii) Bi-odesign-driven Translationa applications and Biotech-d [....] » Read More
Monkeypox (mpox) is a zoonotic disease caused by the Monkeypox virus (MPXV). Recent global outbreaks in non-endemic countries demonstrated their significance as a threat to public health. The main approved and widely used vaccine to fight MPXV infection, MVA-BN®, is based on [....] » Read More
MHC class I complexes can present antigenic peptides that derive from canonical proteins as well as have a sequence produced by post-translational mechanisms such as proteasome-generated peptide splicing. Few pathogen-derived proteasome-generated spliced epitopes have been invest [....] » Read More
Introduction: We had severe respiratory infection cases after COVID-19 pandemic in Japan. At first, three cases of severe influenza that required ventilator management in the 2024-2025 season, which was a major influenza season in Japan, are presented. Case series: Case 1: [....] » Read More
Mesenchymal stem cells (MSCs) and their exosomes (MSC-Exo) are promising for treating infection-induced Acute Respiratory Distress Syndrome (ARDS), mainly via paracrine effects involving immunomodulation, anti-inflammation, antimicrobial activity, and tissue repair, rather than d [....] » Read More
Interferon regulatory factors (IRFs) are classically viewed as transcription factors that induce interferons and antiviral genes during viral infection. Our work reveals that IRF biology extends beyond transcriptional control to include non-canonical functions that shape host res [....] » Read More
The molecular and cellular communication between the host and pathogen is critical to survival of both organisms after Group A Streptcoccus pyogenes (GAS) infection. After attachment and invasion of the pathogen, the human host employs its innate immune system to defend aga [....] » Read More
Objective: People living with HIV (PLHIV) have been disproportionately impacted by the burden of sexually transmitted and blood-borne infections. In this study, we examine the prevalence and incidence of eleven sexually transmitted and bloodborne infections (STBBIs) in PLHIVIV in [....] » Read More
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). To achieve the im-plementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the subcli [....] » Read More
Antimicrobial Photodynamic Therapy (aPDT) has become a potential alternative for treating multidrug-resistant bacterial skin infections like those caused by methicillin-resistant Staphylococcus aureus (MRSA), who are at high risk in older people. One of the main components of aPD [....] » Read More
False positive HIV screening results, while uncommon, carry significant clinical and psychological consequences due to the anxiety and diagnostic uncertainty they generate. One recognised but rare cause is acute Epstein-Barr virus (EBV) infection, which may cross-react with fourt [....] » Read More
A 24-year-old previously healthy woman presented with a one -week history of severe, sharp right occipital headache (pain score 9-10/10). There were no visual, auditory, or focal neurological symptoms, and no history of trauma or systemic illness. Neurological and systemic examin [....] » Read More
Traditionally, infection control has focused on direct person-to-person transmission of Carbapenemase-producing enterobacterales (CPE). However, emerging evidence highlights environmental reservoirs - particularly contaminated clinical hand basins (CHBs) - as critical transmissio [....] » Read More
One Health (recognizes the interdependence of human, animal, plant, and environment health, yet its implementation continues to face context-specific challenges. To address these barriers, the One Health Knowledge Nexus was established in 2023 in support of the Quadripartite One [....] » Read More
Dengue remains a major public health challenge in tropical and subtropical regions, with Brazil accounting for over 70% of reported cases in the Americas during the past decade. In recent years, the number of cases has risen sharply, largely driven by the reemergence of DENV-3 ge [....] » Read More
No medical textbook tells us what the purpose of fever is. Without knowing this, no one in the world can define, test, or treat fever. The current definition, testing, and treatment of fever, which is constructed without knowing what the purpose of fever is, has no scientific bas [....] » Read More
Background: Candida species are the commonest opportunistic fungal infections worldwide. In critically ill patients they may lead to fatal systemic infections. Candidemia is a fatal fungal infection with mortality ranging from 35% to 75%. Of all blood stream infections (BSI), y [....] » Read More
Acute febrile illnesses in tropical countries are commonly attributed to dengue infection; however, other viral pathogens such as Human Parvovirus B19 (B19V) may present with similar clinical and hematological manifestations, leading to diagnostic challenges and possible misclass [....] » Read More
Background: Streptococcus acidominimus is mainly recognized as a veterinary pathogen; however, it can lead to severe infections in humans, especially in those with pre-existing health issues. Proper identification and timely treatment are essential for effectively managing these [....] » Read More
Background: The COVID-19 pandemic has had a significant impact on the world leading to significant morbidity and mortality. The disease was caused by the SARS-CoV-2 virus and can caused severe respiratory illness, as well as a range of other complications depending on presence of [....] » Read More
Background: Conventional microbiologic culture has long been the gold standard in microbiological diagnostics, providing valuable information on pathogen viability and antimicrobial susceptibility. However, multiplex polymerase chain reaction (mPCR) has emerged as a powerful alte [....] » Read More
Background: Long COVID is characterized by persistent multisystem disturbances following SARS-CoV-2 infection. Beyond organ-specific injury, emerging observations suggest that central neuro-immune–lymphatic pathways may play a key role in the evolution of post-viral dysregu [....] » Read More
Background: Long COVID is associated with persistent multisystem symptoms following SARS-CoV-2 infection, yet objective tools to assess ongoing regulatory dysfunction remain limited. Previous research has explored electroacupuncture-according-to-Voll (EAV) diagnostics and me [....] » Read More
Case: A man in his 60s presented with a 7-day history of progressive left periorbital oedema and pruritic vesicular following ipsilateral platelet-rich plasma (PRP) injections for androgenetic alopecia (AA). Pain and swelling started on the day of injection. His past medical [....] » Read More
Cytomegalovirus (CMV) infection remains a leading cause of illness and death after liver transplantation (LT). According to current international guidelines, the two most effective strategies to prevent post-transplant CMV infection are antiviral prophylaxis and pre-emptive thera [....] » Read More
Group B Streptococcus (GBS) frequently colonizes the maternal genital tract and can be a significant cause of severe maternal and neonatal infections. However, there is limited knowledge about the maternal immune and inflammatory responses to GBS colonization and transmission, es [....] » Read More
Introduction: Managing patients admitted to the PICU involves early detection and treatment of shock and hemodynamic stability. Various vascular and extravascular elements must constantly interact to maintain hemodynamic stability. These have been the basis of pediatric age-adjus [....] » Read More
Background: Emerging artemisinin resistance and escalating insecticide resistance threaten recent gains in malaria control across sub-Saharan Africa. Despite this growing heterogeneity in parasite genetics and transmission intensity, intervention strategies are frequently deploye [....] » Read More
Introduction: Sepsis is a life-threatening condition caused by a dysregulated host response to infection resulting in organ dysfunction. Early diagnosis and risk stratification are crucial to reduce morbidity and mortality. Procalcitonin (PCT), a biomarker of bacterial infection, [....] » Read More
Lemierre's syndrome, thrombophlebitis of the Internal Jugular Vein (IJV) with secondary sepsis and infective metastatic lesions, is a rare complication typically of anaerobic bacterial infection of the oropharynx, occurring predominately in the younger adult population. About [....] » Read More
Background: Ultrasonography is the most widely used technique to diagnose echinococcosis; however, challenges in using this technique and the demand on medical resources, especially in low-income or remote areas, can delay diagnosis. We aimed to develop a deep convolutional neura [....] » Read More
Background: AmpC β-lactamase hyperproducing Enterobacterales (ABLHE) are significant causes of bloodstream infections, often associated with multidrug resistance and high mortality. This study aimed to determine the 30-day all-cause mortality rate and its risk factors, to de [....] » Read More
Compartmental models are essential for studying host–pathogen dynamics, evaluating intervention effectiveness, and predicting infection trends. However, the utility of these models for testing competing hypotheses is often overlooked. To address this, we propose a new model [....] » Read More
Respiratory viral infections, including influenza, remain a major global health concern and disproportionately affect individuals with diabetes, who are at increased risk of severe disease and complications. This heightened susceptibility has traditionally been attributed to the [....] » Read More
Background: Streptococcus salivarius is a viridans group streptococcus that forms part of the normal oral flora and is a rare cause of infective endocarditis (IE). Cases are typically associated with poor dentition, dental procedures, or underlying structural cardiac disease. Spl [....] » Read More
Zoonotic parasites present in dogs and cats, such as Toxocara canis and Toxocara cati, pose a risk, especially in recreational areas where people live with their pets. These helminths are responsible for visceral larva migrans syndrome. The objective of this study was t [....] » Read More
Chronic Hepatitis B (CHB) is a significant public health problem affecting approximately 254 million people worldwide and causing 1.1 million deaths annually. Currently, functional cure — defined as HBsAg loss — is achieved at limited rates with existing antiviral tre [....] » Read More
A 24-year-old previously healthy woman presented with a one -week history of severe, sharp right occipital headache (pain score 9-10/10). There were no visual, auditory, or focal neurological symptoms, and no history of trauma or systemic illness. Neurological and systemic examin [....] » Read More
Background: This audit assesses the coverage of first and second line antibiotic regimens for community and hospital acquired sepsis of unknown origin using blood culture isolates at Hampshire Hospitals NHS Foundation Trust. Coverage was compared across two periods: June and July [....] » Read More
Background: Post-sepsis syndrome (PSS) affects up to 50% of survivors, with a mortality exceeding 82% at 5 years and annual costs exceeding $100 billion only in the United States. While immune dysregulation has dominated PSS research, coagulopathy emerges as a silent but critical [....] » Read More
Background: Ventriculoperitoneal (VP) shunts are a well-established treatment for hydrocephalus; however, distal shunt complications such as peritoneal cerebrospinal fluid (CSF) pseudocysts are uncommon and may present with misleading extracranial features. In tuberculosis (TB)&n [....] » Read More
Background: Opportunistic central nervous system (CNS) infections are uncommon but devastating complications of solid organ transplantation (SOT). Although individual pathogens are relatively rare, CNS infections collectively account for up to 10% of transplant-associated complic [....] » Read More
Objective: To present a 72-year-old gentleman with severe Babesiosis and Lyme disease co-infection complicated by multisystem organ failure. Background:Babesiosis is a rare parasitic disease transmitted by ticks that affects red blood cells and can cause serious illness i [....] » Read More
Disseminated Herpes Zoster (DHZ) is typically seen in immunocompromised patients and is rare in immunocompetent individuals, posing a significant diagnostic challenge when it presents atypically. We report a case of a 47-year-old immunocompetent female with no identifiable risk f [....] » Read More
Objective: Endocarditis is a severe, potentially fatal infection of cardiac valves or endocardium, characterized by high morbidity and complex management. This study aims to synthesize contemporary clinical, microbiological, and therapeutic data, highlighting strategies for early [....] » Read More
Background: Suppurative hidradenitis of the breast is an uncommon and diagnostically challenging condition that frequently mimics infectious mastitis or inflammatory breast carcinoma. Its atypical and recurrent nature often leads to extensive diagnostic workups and unnecessary in [....] » Read More
Introduction: Toxoplasmosis, an infection caused by the protozoan Toxoplasma gondii, becomes serious in immunocompromised individuals, ocular toxoplasmosis, and, especially, in cases of congenital infection. Treatment of toxoplasmosis is hampered by the toxicity of conventional m [....] » Read More
This case illustrates a rare and challenging clinical presentation of AIDS with multiple simultaneous opportunistic coinfections, including viral, bacterial, fungal, and parasitic etiologies. We report the case of a 30-year-old male patient admitted to the intensive care unit of [....] » Read More
Takotsubo syndrome, also known as broken heart syndrome, is characterized by transient left ventricular dysfunction. Previous clinical conditions, such as Mycobacterium tuberculosis infection, can act as precipitating factors. It is a rare condition, more common in white women wi [....] » Read More
Male patient, 35 years old, with a personal history of HIV diagnosis one year ago with irregular treatment, and pulmonary tuberculosis infection with complete treatment and discharge due to cure two years ago, resident of a free area, cocaine user, with grade III malnutrition. He [....] » Read More
Community-associated methicillin-resistant Staphylococcus aureus infection is a rare condition, with pneumonia being an uncommon manifestation, especially in previously healthy individuals. A 13-year-old male patient with no previous medical history was admitted to an infectious [....] » Read More
Viral pneumonia caused by the Varicella Zoster virus is a rare but serious complication with a high mortality rate. A 17-year-old male patient, previously healthy, was admitted to an infectious disease hospital with confluent, polymorphic, centripetal papulovesicular rashes that [....] » Read More
The Hepatitis A virus usually causes a self-limiting disease, with fulminant hepatic failure occurring in less than 1% of cases. A 40-year-old white male patient, self-employed, with a personal history of cholecystectomy 11 months prior, with no other comorbidities or ongoing med [....] » Read More
Elevated liver enzymes occur in up to 50 to 90% of patients with dengue, usually with a slight elevation and no clinical significance. In severe cases, the elevation can reach up to ten times the normal value, associated with severe liver inflammation and liver failure in about 0 [....] » Read More
Legionella pneumophila is an aerobe, non-sporulated, facultative intracellular, mobile, gram-negative bacillus. It’s the cause of pneumonia in immunosuppressed patients, usually in a severe form which can expand to multiple lobes, or occasionally, a self-limited mild form, [....] » Read More
Introduction: Ankylosing spondylitis (AS) is a long-term (chronic) disease. The spine, or other areas of the body, become inflamed, causing part of the spinal column to fuse and lose flexibility (ankylosis). AS affects 1 in 200 individuals and is usually diagnosed many years afte [....] » Read More
Introduction: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) significantly contribute to morbidity and mortality worldwide. Understanding the demographic, clinical, microbiological characteristics, and outcomes of AECOPD patients is essential for optim [....] » Read More
Introduction: A fundamental principle of rational antimicrobial therapy is the ability of a drug to achieve concentrations at or above the minimum inhibitory concentration (MIC) at the site of infection. In central nervous system (CNS) infections, cerebrospinal fluid (CSF) drug c [....] » Read More
Cocaine body packing, which is the intentional ingestion of drug-containing packets, has been a major risk factor for fatal consequences if a packet ruptures. Of these, peritonitis secondary to gastrointestinal perforation, though uncommon, is a surgical emergency with high morta [....] » Read More
Introduction: Severe traumatic brain injury (TBI) is defined as a high-risk global condition with a Glasgow Coma Scale score ≤ 8 that continues to challenge global public health, particularly among young adults. Despite the recent advances in the critical care arena, mortality [....] » Read More
Background: Early onset sepsis is a leading cause of morbidity and mortality in neonates requiring early detection and treatment. However, often it can present with non-specific clinical signs and symptoms. It is therefore important to have an effective screening tool which can b [....] » Read More
Background. Latent tuberculosis infection (LTBI) reflects a sustained immune response to Mycobacterium tuberculosis without active disease. Despite global progress toward the WHO “End TB Strategy,” household contacts of TB patients remain at high risk of infection. Ga [....] » Read More
Background: Tuberculosis (TB) infection remains a leading cause of morbidity and mortality worldwide, particularly among people living with HIV/AIDS (PLWHA), in whom coinfection substantially exacerbates disease severity and worsens clinical outcomes. The COVID-19 pandemic prof [....] » Read More
Introduction: Mucormycosis is a severe disease with high mortality caused by fungi of the order Mucorales, mainly in immunocompromised patients. Uncontrolled diabetes mellitus is one of the risk factors for the development of the disease. The purpose of this study was to study ba [....] » Read More
Invasive fungal infections are a growing problem in critically ill patients and are associated with increased morbidity and mortality. Most of them are due to Candida and Aspergillus species. Successful treatment of these infections and the use of antifungal prophylaxis [....] » Read More
We report a 19 year old female who presents for follow up for surgical consultation two years post limb amputation. Two years prior, the patient, then 17 years old, had presented to the emergency department with fever, malaise, and respiratory symptoms, progressing to hypotension [....] » Read More
Background: Nasal decolonization is central to SSI prevention, with mupirocin long regarded as the topical “gold standard” for eliminating Staphylococcus aureus carriage. However, real world implementation exposes a Mupirocin Paradox: programmes that successfully redu [....] » Read More
Surgical Site Infection (SSI) surveillance in cardiac surgery is distorted by a double whammy: systematic under-reporting of true infection rates and reliance on outdated, non inflation adjusted cost data. Enhanced recovery protocols have shortened inpatient stays, but national r [....] » Read More
Background: The long-term impact of coronavirus (COVID)-19 and the possibility of secondary infections have not yet been defined. Because COVID-19 has become a common community infection, patients are often hospitalised with COVID-19 accompanied by unrelated comorbidities (overlo [....] » Read More
Background: The COVID-19 pandemic has affected health workers as one of the groups most at risk of infection. Although vaccines have been manufactured and documented to be a mainstay in prevention and control, many frontline health workers were averse to vaccination due to report [....] » Read More
Background: Clostridium perfringens is a gram-positive, anaerobic, spore-forming bacillus. C. perfringens infections can cause acute and often fatal haemolytic anaemia, mediated by release of the alpha toxin. Aims: C.perfringens endometritis is more commonly seen in the [....] » Read More
People in prison and prison leavers experience disproportionately poorer health outcomes compared to the general population, including a relatively higher prevalence of blood-borne viruses. This is often reported as due to a higher likelihood of risk factors such as sexual practi [....] » Read More
The WHO has identified vaccine hesitancy as one of the main threats to global health. Given that immunisation prevents around 4.4 million deaths worldwide each year, vaccination during pregnancy remains a key intervention for reducing the burden of disease in the first months of [....] » Read More
Title : Changing population immunity to COVID-19 in the context of infection, vaccination, and emerging SARS-CoV-2 variants
Ranjan Ramasamy, ID-FISH Technology, United States
The changing state of protective immunity to COVID-19 in the global population during the six and a half years since COVID-19’s origin in 2019 is analysed in the context of the (i) circulation of SARS-CoV-2 in the population, (ii) widespread use of different types of C [....] » Read More
Title : Extensively drug-resistant bacterial infections: Confronting a global crisis with urgent solutions in prevention, surveillance, and treatment
Yazdan Mirzanejad, University of British Columbia, Canada
Extensively drug-resistant (XDR) bacterial infections represent a growing global crisis with profound impacts on morbidity, mortality, and health system sustainability. These pathogens, resistant to nearly all available antibiotics, are rapidly outpacing our therapeutic options a [....] » Read More
Title : From bench to preclinical evaluation: LL-37-derived peptides for combating orthopedic infections
Vincenzo Pennone, IRCCS Galeazzi Sant’Ambrogio Hospital, Italy
Orthopedic implant-associated infections, frequently caused by Staphylococcus species, remain a major clinical concern due to biofilm formation and the growing threat of antimicrobial resistance. Antimicrobial peptides (AMPs), derived from the human cathelicidin LL-37, represent [....] » Read More
Title : Single step immunoblot tests with recombinant protein antigens for detecting IgG and IgM antibodies in Lyme disease
Ranjan Ramasamy, ID-FISH Technology, United States
Detection of specific antibodies is important for diagnosing Lyme disease (LD). Until recently, this required two separate tests termed the standard two-tier tests (STTTs). The development of one-step immunoblot (IB) tests for detecting IgG and IgM antibodies in patient sera, ter [....] » Read More
Title : Mathematical modeling of COVID-19 dynamics in a West African context
Christabel Emaeyak James, University of Glasgow, United Kingdom
The novel Coronavirus Disease 2019 (covid-19), which emerged in Wuhan, China is a highly infectious disease caused by (SARS-CoV-2) and has significantly affected public health and socio-economic well-being worldwide. Its transmission highlights the potentially important role of t [....] » Read More
Title : TLR9-dependent modulation of adipocyte differentiation by Brucella abortus DNA induces an inflammatory response
Nicole Freiberger, INBIRS-CONICET, Argentina
Brucellosis, caused by Brucella abortus (Ba), remains a neglected zoonosis with significant human morbidity, often associated with chronic inflammatory manifestations. While traditionally regarded as passive reservoirs of energy, adipocytes are now recognized as immunometabolic [....] » Read More
Title : Pneumocystis pneumonia in immunocompetent children
Elmira Rastyamovna Samitova, Sechenov First Moscow State Medical University, Russian Federation
Pneumocystosis, caused by Pneumocystis jirovecii, is an opportunistic infection that is well-studied and occurs in immunocompromised patients, particularly those with HIV infection, as well as in patients with systemic rheumatic diseases and organ transplants who are receiving im [....] » Read More
Title : Regulation of dikaryotic arbuscular mycorrhizal fungal infection in Vigna angularis, Vigna radiata, and Allium tuberosum by Glomus mosseae
Chihang Chang, Kang Chiao International School Linkou Campus, Taiwan
The aim of this study is to investigate whether mycorrhizal fungi infect plant species such as Vigna angularis, Vigna radiata, and Allium tuberosum to promote growth, or whether they instead contribute to disease. Existing literature highlights the complexity of these interaction [....] » Read More
Title : Regulation of dikaryotic arbuscular mycorrhizal fungal infection in Vigna angularis, Vigna radiata, & Allium tuberosum by Glomus mosseae
Yucheng Lin, Kang Chiao International School Linkou Campus, Taiwan
The aim of this study is to investigate whether mycorrhizal fungi infect plant species such as Vigna angularis, Vigna radiata, and Allium tuberosum to promote growth, or whether they instead contribute to disease. Existing literature highlights the complexity of these interaction [....] » Read More
Title : Genomic diversity of Orthohantavirus Andesense (ANDV): Impact of non-synonymous SNVs on gene expression and immune system evasion
Hade Ramos, Pontificia Universidad Catolica de Chile, Chile
Introduction: The Andes virus (ANDV), a rodent-borne Orthohantavirus, causes hantavirus cardiopulmonary syndrome (HCPS) in Chile and Argentina. Its genome comprises three RNA segments: large (L), medium (M), and small (S). The S segment encodes the nucleocapsid (N) and the non-st [....] » Read More
Title : Efficacy and safety of biologic therapies for inflammatory bowel disease: a systematic review from a nursing perspective
Hatice Ceylan, Burdur Mehmet Akif Ersoy University, Turkey
Background: Inflammatory Bowel Disease, comprising Crohn's disease and ulcerative colitis, presents as a chronic, relapsing-remitting inflammatory condition of the gastrointestinal tract, necessitating a multidisciplinary approach to optimize patient outcomes (Schiavoni et al [....] » Read More
Title : E2 ubiquitin-conjugating enzymes regulates dengue virus-2 replication in Aedes albopictus
Xueli Zheng, Southern Medical University, China
Aedes albopictus (Ae. albopictus), an important vector of dengue virus (DENV), is distributed worldwide. Identifying host proteins involved in flavivirus replication in Ae. albopictus and determining their natural antiviral mechanisms are critical to control virus transmission. R [....] » Read More
Title : Emerging burden of non-tuberculous mycobacteria in MGIT-based tuberculosis cultures: Insights from South India
Ambati Mrudula Srinivasulu, Yoda Diagnostics, India
Background: Non-tuberculous mycobacteria (NTM) are increasingly recognized as clinically significant pathogens that can mimic Mycobacterium tuberculosis (MTB) in both clinical presentation and laboratory features. Because of intrinsic drug resistance and overlapping morpholo [....] » Read More
Title : Simultaneous inhibition of terminal oxidases eradicates heterogenous population of Mycobacterium tuberculosis
Arnab Roy, NIPER Hyderabad, India
Background: The persistence of mycobacterium tuberculosis (Mtb) during chemotherapy is a major obstacle to shortening tuberculosis (TB) treatment. A key survival mechanism is the bacterium's metabolic redundancy, specifically the presence of two terminal oxidases for respirat [....] » Read More
Title : CRISPR-based point-of-care diagnostics for real-time surveillance of FMDV and LSDV under the One Health framework
Barsha Mohanty, CrisprBits Private Limited, India
Transboundary animal diseases like Foot-and-Mouth Disease Virus (FMDV) and Lumpy Skin Disease Virus (LSDV) mostly in Cattles are significant threats to livestock health, food security, and rural livelihoods in India. Their rapid spread across species and environments highlights t [....] » Read More
Title : Creutzfeldt-Jakob disease in the Philippines: Diagnostic challenges, clinical features and insights from the first multicenter registry and descriptive analysis
Samuel Ayo, Chong Hua Hospital Fuente Cebu, Philippines
Background: Creutzfeldt-Jakob disease (CJD) is an exceedingly rare, fatal, and rapidly progressive neurodegenerative disorder caused by misfolded prion proteins. In the Philippines, CJD is underrecognized and underreported due to limited access to diagnostic modalities and the ab [....] » Read More
Title : Neuroschistosomiasis in an adolescent presenting with seizure and headache: A case report
Ray John M Salud, Rizal Medical Center, Philippines
Background:Schistosomiasis, a neglected tropical disease, remains endemic in certain regions of the Philippines. This case highlights the importance of considering neuroschistosomiasis in the differential diagnosis of pediatric patients presenting with unexplained neurological sy [....] » Read More
Title : PCR-guided diagnosis and intrathecal salvage therapy for capnocytophaga brain abscess with polymicrobial anaerobic ventriculitis in an immunocompetent host
Alexis Torres Rodriguez, NewYork-Presbyterian Queens Hospital, United States
Background: Brain abscess complicated by ventriculitis is a rare and life-threatening central nervous system (CNS) infection associated with high morbidity and mortality. While common pathogens include streptococci and anaerobic oral flora, Capnocytophaga species are uncommon cau [....] » Read More
Title : Rare cause of septic arthritis: Knee infection by Streptococcus sanguinis post intra-articular injection
Thomas Repantis, General Hospital Agios Andreas, Greece
Objectives: Septic arthritis is a potentially devastating complication of intra-articular injections, typically caused by Staphylococcus aureus or β-hemolytic streptococci. Infections due to viridans streptococci are exceedingly rare. Among them, Streptococcus sanguinis, an [....] » Read More
Title : Severe pharyngo-cervical infection and persistent oropharyngeal–cervical fistula following needle aspiration in a previously irradiated clival chordoma: A case report
Thomas Repantis, General Hospital Agios Andreas, Greece
Objectives: Deep neck infections in previously irradiated tissues are rare but potentially devastating complications. Impaired vascularity, radiation-induced necrosis, and mucosal fragility predispose these patients to severe infections even after minor mucosal interventions. We [....] » Read More
Title : A rare co-occurrence of streptococcus pyogenes meningitis and anti-N-methyl-D- aspartate receptor encephalitis: A case report
Dulce Gregorio Talavera, East Avenue Medical Center, Philippines
Streptococcus pyogenes meningitis is a rare entity, accounting for less than 1% of bacterial meningitis cases, with fewer than thirty cases reported in the past 25 years. It typically affects young children and older adults. In contrast, anti-N-methyl-D-aspartate receptor (NMDAR) [....] » Read More
Title : Legionella, scientific considerations on this pathogen threatening the civilized world. Why not Albania?
Ermira Muco, Mother Theresa University Hospital Center, Albania
Introduction: Legionellosis is an infectious pathology caused by bacteria of the genus Legionella. L. Pneumophilia was recognized as the cause of the disease in 1976. Water reservoirs are its transmitting agents. There are risk factors and predisposing conditions. Travel is a ser [....] » Read More
Title : Evaluating the effectiveness of antimicrobial stewardship on escherichia coli resistance in patients with urinary tract infection: A systematic review and meta-analysis
Paulo Arroyo, George Eliot Hospita, United Kingdom
Objectives: Although several studies have shown that the application of antimicrobial stewardship (AMS) has a positive impact on reduction of antimicrobial resistance and therefore the clinical outcomes of patients, most of the studies were conducted some years ago, and there hav [....] » Read More
Title : Diastolic shock index as an early failure-to-normalize marker of persistent vasodilatory physiology in infection-related critical illness
Himanshu Gul Mirani, Midland Metropolitan University Hospital, United Kingdom
Background: The diastolic shock index (DSI), calculated as heart rate divided by diastolic blood pressure, has emerging utility as a marker of vasodilatory shock and progression to septic shock in the emergency department. While pre-hospital shock index thresholds are recognised [....] » Read More
Title : Challenges in biofilm quantification and the emerging role of hyperspectral imaging
Abhishek Kandikatla, SRM University, India
Biofilms are structured multicellular bacterial communities embedded in a self-produced extracellular matrix that can adhere to any biotic or abiotic surface. Biofilms associated infections, occurring in wounds, dental plaques, urinary tract and its persistence on medical devices [....] » Read More
Title : Intravenous drug users and spondylodiscitis as an associated infection: A serious public health problem at the global level, including in Albania
Neada Hoxha, Regional Hospital of Diber, Albania
Introduction: Intravenous drug use (IVDU) is a growing global health concern associated with severe infections and comorbidities. Among these, spondylodiscitis has been increasingly reported across Europe and is now observed in Albania.Data from the Institute of Public Health (IH [....] » Read More
Title : A comparison of current treatments for clostridioides difficile infection in adults and children
Daniel S. Bednarik, Semmelweis University, Hungary
Introduction: Clostridioides difficile infection (CDI) is one of the most common and severe causes of healthcare-associated diarrhea and is associated with substantial morbidity and mortality. Although CDI has traditionally posed a major clinical challenge in adult healthcare set [....] » Read More
Title : Archaeological and genetic evidence of earliest records of plague endemic (5,100 – 5,600 Years BP) and its especial relevance to zoonotic pathogen ecology, human resilience, public awareness, and health policy
Qian Wang, Texas A&M University College of Dentistry, United States
Deadly infectious diseases such as the medieval Black Death (plague) and 20th-century Ebola have caused catastrophic loss of human life and generated great fear in the past and in contemporary human populations. Infectious disease epidemics persist as a threat and certainly will [....] » Read More
Title : Optimizing oral cholera vaccine allocation: Pre-emptive vs. reactive strategies under uncertainty
Jong Hoon Kim, International Vaccine Institute, Korea, Republic of
Constrained global oral cholera vaccine (OCV) supplies force difficult trade-offs between pre-emptive and reactive deployment in sub-Saharan Africa. To address this, we developed an analytical and simulation framework to optimize OCV allocation to minimize costs that account for [....] » Read More
Title : Structure-conserved, sequence-divergent RNA motifs in Nipah virus reveal mutation resistant therapeutic targets missed by protein centric design
Abhinav Iyer, Dougherty Valley High School, United States
Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus emerging in South and Southeast Asia. With mortality rates ranging from 40–70%, it is classified by the World Health Organization as a priority pathogen. Despite its major clinical impact, the regulatory potent [....] » Read More
Title : Immunogenicity and safety of inactivated SARS-CoV-2 vaccine (CoronaVac) using a two-dose primary protocol in children and adolescents (Immunita-002, Brazil): A phase IV one-year follow-up
Camila Amormino Corsini, Oswaldo Cruz Foundation (Fiocruz Minas), Brazil
The immune response induced by SARS-CoV-2 vaccination in children and adolescents is not yet well defined regarding the intensity and duration of protective immunity in the medium and long term, which may indicate the need for booster doses and support public health decisions. Gi [....] » Read More
Title : Discovery of reintroduction source and amplification vectors of highly pathogenic avian influenza
Amanda Fox, Animal Research Initiative, United States
The spread of Highly Pathogenic Avian Influenza (HPAI) has recently expanded to unprecedented proportions. Its existence in livestock has been well documented with the primary animals of concern being chickens, ducks, turkeys, game birds, bovine, swine, sheep, mink, and foxes. Wi [....] » Read More
Title : Structural studies of the hemagglutinin-membrane interaction
Luke Perera, The Francis Crick Institute, United Kingdom
The viral fusion protein hemagglutinin (HA) is the predominant influenza surface glycoprotein and mediates engagement with and entry into host cells. Influenza A virus HAs are categorised into two broad and immunologically distinct phylogenetic groups. Group 2 HA subtypes include [....] » Read More
Title : Severe legionella pneumonia case series at an urban academic medical center
Sasha Leibholz, New York Presbyterian Columbia/Cornell, United States
An outbreak of Legionnaires’ disease began in New York City in July 2025. In this abstract we present a series of three severe cases of Legionella pneumonia seen in an urban academic emergency department: Case 1: A 71-year-old male with a history of hypertension, hy [....] » Read More
Title : Severe legionella pneumonia case series at a urban academic medical center
Lauren Gruffi, New York Presbyterian Columbia/Cornell, United States
An outbreak of Legionnaires’ disease began in New York City in July 2025. In this abstract we present a series of three severe cases of Legionella pneumonia seen in an urban academic emergency department: Case 1: A 71-year-old male with a history of hypertension, hy [....] » Read More
Title : SEP-1 compliance metrics following the sepsis tool implementation project, utilizing the epic 2.0 sepsis prediction model
Terri Menser, Mayo Clinic, United States
Mayo Clinic Florida (MCF) was one of the early adopters of Epic’s 2.0 sepsis prediction tool nationwide. Beginning in early 2024, we launched the inpatient model, which included the implementation of an EHR integrated timer and checklist in July. These tools were deployed t [....] » Read More
Title : A cog in the weil
Anam Azhar, Texas Health Resources, United States
We present the case of a 46-year-old male with well-controlled HIV infection on antiretroviral therapy who presented with a four-day history of fever, malaise, and jaundice. The patient, a pilot with recent travel to the United Kingdom and prior travel throughout North America, C [....] » Read More
Title : Sporotrichosis: Case report and review of sporotrichosis — clinical presentation, diagnosis, antifungal susceptibility, and United States epidemiology
Taylor Hermann, University of South Florida, United States
Sporotrichosis is a subacute to chronic fungal infection caused by Sporothrix species, typically presenting with cutaneous or lymphocutaneous disease. Although traditionally associated with Latin America, zoonotic and environmental transmission has become increasingly recognize [....] » Read More
Title : Sepsis-induced gastrointestinal dysfunction- An atypical initial presentation of infective endocarditis
Kesava Manikanta Achuta, Garden City Hospital, United States
Introduction: Infective endocarditis (IE) is a life-threatening condition with mortality approaching 30% with highly variable presentation. Although fever and cardiac murmurs are classic, their absence does not exclude IE. Among persons who inject drugs, right-sided IE is common [....] » Read More
Title : Co-infection of Pneumocystis jirovecii and Mycobacterium tuberculosis in a patient with granulomatosis with polyangiitis: A diagnostic and therapeutic challenge
Maria Soura, National and Kapodistrian University of Athens, Greece
Background: Pneumocystis jirovecii pneumonia (PJP) is a rare but serious opportunistic infection affecting immunocompromised individuals. Although Pneumocystis organisms may colonize healthy lungs, they can cause severe pneumonia in patients with impaired immunity, particula [....] » Read More
Title : Epidemiological profile of gestational toxoplasmosis in Brazil from 2019 to 2024
Luiz Filippe Simao Soares, Federal University of Espírito Santo (UFES), Brazil
Background: Gestational toxoplasmosis, caused by the protozoan Toxoplasma gondii, is an infection that generates significant concern due to the risks associated with vertical transmission from mother to fetus, which occurs due to the parasite's ability to cross the placental [....] » Read More
Title : Virulence factors and genetic diversity of Trypanosoma cruzi: Implications for pathogenesis mechanisms
Lucas Granja Cotrik, University Veiga de Almeida, Brazil
Introduction: The genetic diversity of Trypanosoma cruzi, classified into different DTUs, has a major influence on the pathogenic mechanisms of Chagas disease. This variability accounts for differences in the expression of virulence factors such as trans-sialidases and mucins, af [....] » Read More
Title : Atypical neurological and ophthalmic debut of AIDS with dual opportunistic infection: Cryptococcal meningitis and cytomegalovirus retinitis
Yaira Eloisa Mendoza Montijo, Autonomous University of Baja California, Mexico
Background: Opportunistic infections of the central nervous system (CNS) and retina are severe complications of advanced HIV/AIDS. However, their simultaneous presentation as the initial manifestation of AIDS is uncommon. The diagnostic challenge increases when the early cli [....] » Read More
Title : Risk factors of the early onset of catheter-related bloodstream infection among hemodialysis patients admitted at a tertiary hospital: A 5-year retrospective analysis (2018–2022)
Devin Edjohn Michael Aballe, Vicente Sotto Memorial Medical Center Department of Internal Medicine, Philippines
Introduction: Catheter-related bloodstream infection (CRBSI) remains a major cause of morbidity and mortality among hemodialysis (HD) patients worldwide. In low- and middle-income settings, limited vascular-access options and prolonged catheter use heighten infection risk. Local [....] » Read More
Title : Catastrophic unmasking: Fatal tuberculosis-associated IRIS presenting as acute liver failure in pregnancy
Carmela Bianca Villacete, St Luke's Medical Center - Quezon City, Philippines
Background: Immune Reconstitution Inflammatory Syndrome (IRIS) is a severe and potentially fatal inflammatory condition that can occur in severely immunocompromised patients, such as those with HIV, after initiating antiretroviral therapy (ART). The syndrome is triggered by [....] » Read More
Title : Prevalence and microbiologic profile of catheter-related bloodstream infections in chronic kidney disease patients in Baguio General Hospital and Medical Center
Cinderella Gerna, Dennis Molintas District Hospital, Philippines
Introduction: Central venous catheters (CVCs) are utilized as access for hemodialysis (HD) in emergency settings in Baguio General Hospital and Medical Center (BGHMC). CVCs remain the primary vascular access of chronic kidney disease (CKD) patients undergoing hemodialysis until [....] » Read More
Title : A case of neurosyphilis presenting as dyschromatopsia in an immunocompetent Filipino adult
Sharrah Mae Tan, Chong Hua Hospital Fuente Cebu, Philippines
Background: Syphilis, caused by Treponema pallidum, is a multisystemic sexually transmitted infection recognized as a “great imitator.” Ocular syphilis, a manifestation of neurosyphilis, can occur at any stage and affect nearly all ocular structures presenting wi [....] » Read More
Title : Clinical profile of candidemia in children: A 10-year experience from a tertiary care centre in India
Abhipsha Anuranjana, Christian Medical College, India
Background: Systemic fungal infections cause significant morbidity and mortality in children. Antifungal resistance is a matter of concern, as choice of antifungal therapy for empirical and therapeutic purposes is guided by existing sensitivity patterns among Candida isolates. [....] » Read More
Title : Vegetable-associated Escherichia coli ST446 carrying blaCTX-M-1 and mcr-1 raises concerns regarding difficult-to-treat foodborne infections
Eliana Guedes Stehling, University of Sao Paulo, Brazil
Antimicrobial resistance is a pressing global issue with significant implications for human health. The presence of human bacterial pathogens resistant to last-line treatments in ready-to-eat vegetables is particularly concerning, as it compromises food safety and poses a serious [....] » Read More
Title : Modeling climate effects on mosquito abundance in an arid environment: Link to vector-borne disease risk
Haneen I Eldos, Weill Cornell Medicine, Qatar
Background: Vector-borne diseases (VBDs) are increasingly recognized in Qatar, where mosquito-borne diseases have been reported more frequently in recent years. Qatar’s arid climate, with occasional rain, high humidity, and mild winters, creates windows suitable for mosquit [....] » Read More
Title : Early prosthetic joint infection of the knee due to clostridiodes difficile following episode of colitis
Lily Zheng, Rutgers Robert Wood Johnson Medical School, United States
Introduction: Extraintestinal manifestations of Clostridioides difficile infection (CDI) are rare, occurring in <1% of reported CDI cases. Risk factors include intestinal barrier disruption, previous hospitalization, advanced age (>65 years), and use of broad-spec [....] » Read More