Title : Controlling pulmonary inflammation during respiratory virus infection
Abstract:
Virus infection causes rapid induction of antiviral and inflammatory genes in infected cells, leading to an antiviral state in the host. Inflammation in the early stages of the infection is beneficial; however, hyperinflammation, caused by cytokine storm, contributes to the pathogenesis. Our lab has been studying the delicate balance between the antiviral and inflammatory arms of the host-virus interaction. Our studies using cells and mice identified new ways the host controls the inflammatory responses to curb cytokine storm and eventually the inflammatory response. These studies have translational impacts against specific respiratory viruses.
