Title : The characterization of a rhamnosilated triterpenic saponin from Quillaja saponaria Mol. reveals novel adjuvant, antibacterial, antiviral and antifungal properties
Abstract:
Quillaja is a rich source of triterpenic saponins known for their notable biological activities. In this study, we report the isolation, chemical characterization, and key biological properties of a novel saponin fraction designated as FR, which differs from traditional Quillaja saponins. Fraction FR primarily consists of a unique bidesmosidic glycoside of quillaic acid characterized by LC-MS/MS. It exhibits significant in vitro antibacterial, antifungal, and antiviral activities, as well as in vivo immunostimulant effects. These findings expand the potential applications of Quillaja saponins, particularly as vaccine adjuvants and antimicrobial or antiviral agents with promising clinical relevance.
