Hypothesis linking the major predisposing factors for multiple sclerosis including Epstein-Barr virus infection to its etiology

Title : Hypothesis linking the major predisposing factors for multiple sclerosis including Epstein-Barr virus infection to its etiology

Abstract:

Epstein–Barr virus infection and Human Leukocyte Antigen Class II allele DRB1*1501 increase the risk of developing multiple sclerosis, an autoimmune disease of the central nervous system. Human endogenous retroviral envelope proteins, molecular mimicry and neuroinflammation have been linked to multiple sclerosis. While the pathology of multiple sclerosis has been well-studied, the molecular and cellular mechanisms underlying interactions between the different predisposing factors in its etiology are not clear and are now presented in a new overarching hypothesis. Besides advancing understanding of multiple sclerosis etiology and promoting further research, this hypothesis can generate new approaches for treating multiple sclerosis.

Biography:

Ranjan Ramasamy obtained a BA and PhD from the University of Cambridge, UK. He has held academic appointments in the UK and abroad including Australia, Sri Lanka and the USA. He was the Chairman of the National Science Foundation of Sri Lanka, and held Professorial appointments in Biochemistry, Immunology and Life Sciences. He was a member of the Board of Governors of the International Centre for Genetic Engineering and Biotechnology (ICGEB), and a member of Committee for Scientific Planning and Review (CSPR) of the International Council for Science (ICSU) for several years. He has 300 publications pertaining to Biochemistry, Immunology and Infectious Diseases.