Title : OnePeru: Peruvian bioinformatics platform to contribute to the fight against antimicrobial resistance
Abstract:
OnePeru: Integrated genomic database for surveillance, diagnosis, management, and treatment of antimicrobial resistance is a project that involved developing a database that integrates carefully curated genomic information with antimicrobial profiling results from samples from human, animal, and environmental environments, adopting a One Health perspective. The platform facilitates tracking the origin of bacteria, understanding their phenotypic and genotypic resistance profile, determining dissemination dynamics and routes, and early identification of high-risk clones and/or emerging resistance mechanisms. It consists of three stages:
Phase 1: The "OnePeru" bioinformatics platform was designed and implemented. Additionally, open Peruvian genome sequences were collected and curated, following best practices for quality assessment, for the four antimicrobial-resistant bacteria of critical priority to the WHO: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, from other open-access databases to consolidate the information into the "OnePeru" bioinformatics platform.
In Phase 2, the OnePeru platform was fed with new Peruvian genome sequences from the four antimicrobial-resistant bacterial isolates from clinical samples obtained from three regions of Peru, the selected areas being Lima, San Martín, and Cusco.
In Phase 3, the final stage, Peruvian genomic sequences of four bacterial isolates resistant to WHO critical priority antimicrobials from hospital/community wastewater and companion animals were also included.