Background: Recurrent Klebsiella pneumoniae pyogenic liver abscess (KPLA) is clinically important because persistent or recurrent cavities may reflect ongoing infection, inadequate source control, or an occult gastrointestinal lesion. We aimed to develop a simple, literature-in [....] » Read More
Background: Postoperative pelvic fluid collections after hysterectomy commonly trigger empiric broad-spectrum antimicrobial therapy, yet sterile postoperative collections and topical hemostatic agents may mimic abscess on imaging. We used a solved postoperative gynecologic oncolo [....] » Read More
Background: Solved clinical cases can be converted into worked examples—cases with a known diagnosis and outcome that are used to teach clinical reasoning—but building these from real records is time-intensive. We developed a mentored AI workflow to transform a de-ide [....] » Read More
Background: Infectious-disease management requires clinicians to integrate host factors, epidemiology, examination, laboratory and imaging data, microbiology, treatment response, antimicrobial stewardship, prevention, and communication under uncertainty. Yet learners have limited [....] » Read More
Summary: Acinetobacter junii is a rarely reported cause of human infection. We report a case of A.junii bacteremia in a 79-year-old man with end-stage renal disease on hemodialysis who presented with lower extremity cellulitis and sepsis. Blood cultures obtained prior to antibiot [....] » Read More
Persistent cervical lymphadenopathy in children is most commonly associated with self-limited infectious diseases. However, prolonged lymph node enlargement, particularly when accompanied by atypical clinical features, should prompt investigation for less common etiologies, inclu [....] » Read More
Canine visceral leishmaniasis is a major parasitic disease of public health importance in endemic areas, but diagnosis can be challenging because clinical manifestations are variable and conventional methods may differ in sensitivity according to the biological specimen and analy [....] » Read More
Cerebral schistosomiasis (CS) is a rare, severe ectopic manifestation of Schistosoma infection, with Schistosoma japonicum exhibiting a strong predilection for cerebral parenchyma. Its presentation as a solitary pseudotumoral mass frequently mimics primary glial neoplasms such as [....] » Read More
Background: Sustained viral suppression is a key goal of HIV care, yet clinical, psychosocial, and programmatic vulnerabilities may interact in complex ways among women living with HIV. Machine learning approaches can help identify individuals at risk of unfavorable treatment out [....] » Read More
Background Typhoid fever is a serious infection that primarily affects humans, with around 20 million cases reported each year, mostly in low-and middle-income countries (LMICs). Continuous monitoring of Salmonella enterica serovar Typhi (S. Typhi) in these endemic areas is cruc [....] » Read More
Title : Diagnostic approaches, predictive and prognostic assessments, monitoring, treatment & management of infectious diseases and disease prevention
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
A new and upgraded approach to the diseased states and wellness, and to re-shape tomorrow’s healthcare, whilst doing it today, resulted in a new global trend in the healthcare services, namely, Personalized and Precision Medicine (PPM). PPM as a Unique Entity demonstrating [....] » Read More
Title : The accelerated timeline: Human ecology, climate change, and the next global outbreak
Claudia Ferreira, Sorbonne University, France
Will be Updated Soon...
Title : Climate changes & increasing pollution and respiratory illnesses
Yazdan Mirzanejad, University of British Columbia, Canada
Climate change, global warming, and environmental pollution are increasingly recognized as major drivers of respiratory morbidity and mortality worldwide. Rising temperatures, more frequent wildfires, prolonged pollen seasons, desert dust, ground-level ozone, and exposure to fine [....] » Read More
Title : Invasive group A streptococcal infections in children: Current therapeutic challenges
Elena Chiappini, University of Florence, Italy
Group A Streptococcus (GAS) is responsible for a broad spectrum of infections in children, ranging from common and usually self-limiting diseases to rapidly progressive and life-threatening invasive infections. Invasive GAS (iGAS) disease includes bacteremia, pneumonia, osteoarti [....] » Read More
Title : Climate changes & increasing tickborne illnesses
Yazdan Mirzanejad, University of British Columbia, Canada
Climate change is reshaping the epidemiology of tick-borne diseases by altering vector survival, seasonal activity, geographic distribution, and interactions among ticks, wildlife, domestic animals, and humans. Warmer temperatures, milder winters, prolonged vegetation periods, an [....] » Read More
Title : Characterizing the mechanism of action for antimalarial compound 2714-19
Nastassja Matus, Brown University, United States
Malaria remains a major global health challenge, with an estimated 282 million cases and 610,000 deaths in 2024, according to the WHO World Malaria Report 2025. Plasmodium falciparum (P. falciparum) is the deadliest human malaria parasite. Although effective antimalarial drugs ar [....] » Read More
Title : Characterizing the mechanism of action for antimalarial compound 2714-19
Ximenna Garcia Rivera, Brown University, United States
Malaria remains a major global health challenge, with an estimated 282 million cases and 610,000 deaths in 2024, according to the WHO World Malaria Report 2025. Plasmodium falciparum (P. falciparum) is the deadliest human malaria parasite. Although effective antimalarial drugs ar [....] » Read More
Title : Microbiological and parasitological quality of Lactuca sativa L. sold at farmers’ markets in Goiânia, Goiás
Adevaldes Pereira Carrijo Neto, Centro Universitário de Goiatuba - Unicerrado, Brazil
Background: Fresh leafy vegetables eaten raw can carry foodborne bacteria and intestinal parasites when contamination occurs during cultivation, transport, handling or sale. Farmers’ markets are an important source of fresh produce in Brazil, but sanitary conditions vary co [....] » Read More
Title : A multicenter genome-wide association study of leprosy in Brazil
Frederico Marianetti Soriani, Federal University of Minas Gerais, Brazil
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Despite substantial progress in controlling its transmission, leprosy continues to affect a considerable number of individuals worldwide. The disease is characterized by a broad clinical spectrum associated w [....] » Read More
Title : Role of perfusion index (PI) as a screening tool in early detection of dengue shock syndrome (severe dengue) at a tertiary care centre in Northwestern India – a prospective observational study
Vaishakh Vinod Pisharody, Department of Pediatrics, AIIMS Jodhpur, India
Research Question Can Perfusion Index (PI), a non-invasive pulse oximetry-derived parameter, serve as an effective bedside screening tool for identifying severe dengue and dengue shock syndrome in children? Aims and Objectives To evaluate the utility of PI in early identificat [....] » Read More
Title : Transfer learning framework for climate-dependent disease prediction: coupling compartment model with deep learning
Weide Li, Lanzhou University, China
Influenza-like illness (ILI) serves as a representative climate dependent disease due to its climate sensitivity, widespread transmission, and significant impact on public health and societal functioning, highlighting the urgent need for reliable ILI prediction techniques that co [....] » Read More
Title : Efficacy and safety of Tegoprazan–Amoxicillin dual therapy versus bismuth-containing quadruple therapy for helicobacter pylori eradication: A systematic review and meta-analysis
Alaa Babonji, Ministry of National Guard Health Affairs, Saudi Arabia
Helicobacter pylori infection but is limited by treatment complexity and adverse events. Tegoprazan, a potassium-competitive acid blocker (P-CAB), has emerged as a promising alternative due to its potent acid-suppressive properties. We conducted a systematic review and meta-analy [....] » Read More
Title : Pediatric necrotizing pneumonia: diagnostic strategies, therapeutic approaches, and clinical outcomes
Mariana Fonseca Melo, Dom Pedro II University Center (UNIDOM), Brazil
Background and Objective: Pediatric necrotizing pneumonia (PNP) is a rare and severe complication of community-acquired pneumonia characterized by pulmonary parenchymal destruction and necrotic cavitation. This study aimed to analyze factors associated with PNP, with emphasis on [....] » Read More
Title : Prevalence, antimicrobial susceptibility, and risk factors of carbapenem-resistant Pseudomonas aeruginosa in tertiary referral hospitals in Rwanda, 2023 to 2025
Denyse Mugwaneza, Rwanda Biomedical Centre, Hungary
Background: Pseudomonas aeruginosa (PA) is among the major causes of nosocomial infections. Carbapenem-resistant P. aeruginosa is also listed in the critical category of the priority pathogens for which new antibiotics are urgently needed. However, data on PA and its antimicrobia [....] » Read More