Brucella species comprise a group of Gram-negative bacteria known for causing brucellosis, a zoonotic infectious disease affecting both animals and humans. These bacteria, including species like B. abortus, B. melitensis, and B. suis, primarily infect domesticated animals such as cattle, goats, and pigs. Humans typically contract brucellosis through direct contact with infected animals or consumption of unpasteurized dairy products. Brucellosis manifests with a range of symptoms, including fever, fatigue, joint pain, and gastrointestinal issues. The chronic nature of the disease makes diagnosis challenging, and its impact on livestock poses economic concerns for agricultural communities. Prevention strategies involve vaccination of animals, pasteurization of dairy products, and adherence to proper hygiene practices during agricultural and veterinary activities. Efforts to control brucellosis also emphasize global cooperation and surveillance due to its potential as a bioterrorism agent. Enhanced biosecurity measures, research into new vaccines, and improved diagnostic tools are crucial components of a comprehensive approach to mitigate the impact of Brucella species on both animal and human health.