Isospora infections have a global distribution, but the prevalence varies across regions with different socio-economic conditions. The risk of infection is higher in areas with inadequate sanitation, limited access to clean water, and poor hygiene practices. Outbreaks have been reported in both developing and developed countries, highlighting the importance of understanding the socio-environmental factors influencing the transmission of Isospora. In regions where HIV/AIDS is prevalent, Isospora infections are a significant concern due to the increased susceptibility of immunocompromised individuals. Additionally, travel-associated cases have been documented, emphasizing the potential for transmission in tourist destinations with suboptimal sanitary conditions. Public health considerations for Isospora infections involve implementing measures to improve sanitation, access to clean water, and health education. Surveillance and monitoring of water quality are essential components of preventing outbreaks. In HIV/AIDS populations, routine screening for Isospora and other opportunistic infections is crucial for early detection and management. Educational campaigns targeting both healthcare providers and the general public can raise awareness about the risk factors and preventive measures for Isospora infections. Research into the epidemiology and genetic diversity of Isospora species contributes to a better understanding of transmission dynamics and informs public health strategies aimed at reducing the burden of isosporiasis worldwide.