HIV/AIDS remains one of the most pressing global health challenges, with significant impacts on individuals, communities, and societies worldwide. Human Immunodeficiency Virus (HIV) weakens the immune system, making individuals vulnerable to opportunistic infections and diseases. Acquired Immunodeficiency Syndrome (AIDS) represents the advanced stage of HIV infection, characterized by severe immunosuppression and the onset of life-threatening illnesses. Despite advances in treatment and prevention, HIV/AIDS continues to disproportionately affect marginalized populations, including LGBTQ+ individuals, people of color, and those living in resource-limited settings. Efforts to combat HIV/AIDS encompass a multifaceted approach, including widespread testing, access to antiretroviral therapy, education, and stigma reduction. While progress has been made, ongoing dedication and collaboration are essential to achieving the goal of ending the HIV/AIDS epidemic globally.