Infectious agents pose significant challenges to global health, and the emergence of new pathogens contributes to ongoing public health concerns. Emerging infectious diseases may result from zoonotic spillover events, where pathogens jump from animals to humans, or from the evolution of existing pathogens with increased virulence or drug resistance. Examples of emerging infectious agents include novel influenza strains, coronaviruses (as seen with SARS-CoV-2), and antibiotic-resistant bacteria like Methicillin-resistant Staphylococcus aureus (MRSA). Globalization, climate change, deforestation, and increased human-animal interactions amplify the risk of infectious disease outbreaks. Addressing emerging infectious threats requires a multidisciplinary approach involving surveillance, rapid diagnostics, international collaboration, and research into therapeutics and vaccines. The One Health concept, which recognizes the interconnectedness of human, animal, and environmental health, is crucial for understanding and mitigating the impact of infectious agents on a global scale. Preparedness and response strategies involve strengthening healthcare systems, enhancing laboratory capacities, and promoting public health education. Global initiatives, such as the World Health Organization's International Health Regulations, aim to facilitate coordinated responses to infectious disease outbreaks and promote a united front against emerging threats to human health.