Leprosy has been a persistent public health challenge, particularly in impoverished regions with inadequate healthcare infrastructure. The disease's prevalence is unevenly distributed, with countries like India, Brazil, and Indonesia reporting the highest number of cases. Efforts to eliminate leprosy globally have been underway, with the World Health Organization's (WHO) goal of achieving zero leprosy-related disabilities by 2020. Various strategies, including active case finding, contact tracing, and multidrug therapy, have contributed to significant reductions in leprosy prevalence. Integration of leprosy services into general healthcare systems, community awareness campaigns, and destigmatization efforts aim to improve early case detection and treatment adherence. Leprosy's socioeconomic impact extends beyond health consequences, affecting individuals' livelihoods and social integration. Discrimination and stigma associated with leprosy persist in many societies, leading to isolation and marginalization of affected individuals. Research into the immunology of leprosy and the development of new diagnostic tools and treatments continue to enhance our understanding of the disease. Global collaboration and commitment are essential for achieving sustained leprosy elimination and addressing the broader social and economic challenges faced by individuals affected by this ancient and stigmatized disease.