Musculoskeletal infections encompass a diverse group of conditions affecting bones, joints, muscles, and associated tissues. These infections can be caused by bacteria, viruses, fungi, or parasites. Osteomyelitis, a bacterial infection of the bone, often results from the hematogenous spread of pathogens, direct contamination, or adjacent soft tissue infections. Septic arthritis involves the invasion of infectious agents into joint spaces, leading to inflammation and joint damage. Soft tissue infections, such as cellulitis or myositis, affect muscles and surrounding tissues. Clinical presentation varies depending on the specific type of musculoskeletal infection. Common symptoms include localized pain, swelling, redness, and limited range of motion. Systemic signs such as fever and malaise may also be present, particularly in more severe cases. Early diagnosis is crucial for effective management, often involving imaging studies like X-rays, CT scans, or MRI, along with laboratory tests and cultures.