MHC class I complexes can present antigenic peptides that derive from canonical proteins as well as have a sequence produced by post-translational mechanisms such as proteasome-generated peptide splicing. Few pathogen-derived proteasome-generated spliced epitopes have been invest [....] » Read More
Background: Cryptococcus gattii, endemic to tropical and subtropical regions, is a primary fungal pathogen capable of causing severe meningoencephalitis in immunocompetent individuals. Its clinical course is often complicated by raised intracranial pressure (ICP), the format [....] » Read More
Background: In developing countries such as Uganda, intestinal parasitic infections and schistosomiasis remain a serious threat to public health. Local epidemiological data is critical for prevention and control of the disease. This study aimed to determine the prevalence, i [....] » Read More
Background: Streptococcus acidominimus is mainly recognized as a veterinary pathogen; however, it can lead to severe infections in humans, especially in those with pre-existing health issues. Proper identification and timely treatment are essential for effectively managing these [....] » Read More
Background: The COVID-19 pandemic has had a significant impact on the world leading to significant morbidity and mortality. The disease was caused by the SARS-CoV-2 virus and can caused severe respiratory illness, as well as a range of other complications depending on presence of [....] » Read More
The aim the present study was to investigate the impact of novel pentavalent organobismuth and organoantimony complexes on membrane integrity and their interaction with DNA, activity against Sb(III)?sensitive and ?resistant Leishmania strains and toxicity in mammalian peritoneal [....] » Read More
The COVID-19 pandemic prompted a surge in the global consumption of natural remedies, with many individuals turning to plant-based drinks believed to boost immunity and alleviate symptoms. This study explored the perception, frequency, and types of immune-enhancing beverages co [....] » Read More
Aims: To highlight the challenges in diagnosing NTM-PD in tuberculosis endemic countries. Objectives: Document the clinical profile of patients who presented with tuberculosis-like symptoms but were later diagnosed with NTM-PD. Review the diagnostic methods used to di [....] » Read More
Introduction: Acinetobacter baumannii is one of the main bacterial pathogen associated with nosocomial infections, particularly for VAP in ICU. It is his characteristic in developing multidrug resistance and poses significant treatment challenges with mortality e [....] » Read More
Title : Extensively drug-resistant bacterial infections: Confronting a global crisis with urgent solutions in prevention, surveillance, and treatment
Yazdan Mirzanejad, University of British Columbia, Canada
Extensively drug-resistant (XDR) bacterial infections represent a growing global crisis with profound impacts on morbidity, mortality, and health system sustainability. These pathogens, resistant to nearly all available antibiotics, are rapidly outpacing our therapeutic options a [....] » Read More
Title : Bioterrorism through the ages: Historical perspective, emerging threats, and medical countermeasures
Claudia Ferreira, Sorbonne University, France
Bioterrorism is defined as “the intentional release or threat of release of biologic agents—viruses, bacteria, fungi, or their toxins—to cause disease or death in humans, animals, or crops.” Bioterrorism remains a significant and evolving threat to public [....] » Read More
Title : OnePeru: Peruvian bioinformatics platform to contribute to the fight against antimicrobial resistance
Pool Marcos Carbajal, University of San Martin de Porres, Peru
OnePeru: Integrated genomic database for surveillance, diagnosis, management, and treatment of antimicrobial resistance is a project that involved developing a database that integrates carefully curated genomic information with antimicrobial profiling results from samples from [....] » Read More
Title : Acceptability of mass drug administration for lymphatic filariasis in Baglung municipality of Nepal: A mixed-method study
Muskan Pudasainee, Pokhara University, Nepal
Introduction: Lymphatic filariasis (LF), a neglected tropical disease, remains a significant public health challenge in endemic regions including Baglung Municipality of Nepal. This study investigates the acceptability of mass drug administration (MDA) for LF in Baglung Municipal [....] » Read More
Title : Decade-long surveillance of rotavirus genotype diversity pre- and post-vaccine introduction among under-five children with Diarrhoea at the university of Ilorin teaching hospital, Nigeria (2013–2023)
Amadu Dele Ohinoyi, University of Ilorin Teaching Hospital, Nigeria
Background: Rotavirus remains a leading cause of severe childhood diarrhoea, contributing significantly to under-five morbidity and mortality worldwide. In August 2022, Nigeria introduced the rotavirus vaccine into its national immunization program. Continuous surveillance of cir [....] » Read More
Title : Rapid identification of Bacillus anthracis biomarkers via mass spectrometry: A review and its implications for biodefense
Jacqueline Roberta Soares Salgado, Engineering Military Institute (IME) of the Brazilian Army, Brazil
The rapid and unequivocal identification of pathogenic biological agents is a pivotal cornerstone in biodefense and chemical defense, particularly in light of the persistent threat of bioterrorism. Bioterrorism poses a significant global hazard, with Bacillus anthracis, the Abstr [....] » Read More
Title : Amplicon-based nanopore sequencing reveals molecular evolution and zoonotic potential of Muju virus (Orthohantavirus puumalaense) in Craseomys regulus, Republic of Korea
Jin Won Song, Korea University College of Medicine, Korea, Republic of
Orthohantavirus puumalaense causes hemorrhagic fever with renal syndrome (HFRS) in Europe, with Puumala virus (PUUV) representing the primary genotype. During 2019-2023, 30 EU/EEA countries reported 14,798 cases of hantavirus infection and PUUV was the most commonly identified pa [....] » Read More
Title : Outbreak of pulmonary histoplasmosis in Cienfuegos province
Darehyne Avila Pina, University of Medical Sciences of Cienfuegos, Cuba
Histoplasmosis is a systemic mycosis of worldwide distribution caused by the inhalation of Histoplasma capsulatum spores. It is characterized by wide clinical variability depending on the fungal load, the patient's immunological status and the virulence of the germ. Object [....] » Read More
Title : Diverse clinical presentations of brucellosis in a tertiary care centre
Ujwal Ramrao Shinde, Bharati Vidyapeeth Deemed University , India
Brucellosis, an endemic zoonosis in many countries, is caused by bacteria of the genus Brucella, a Gram-negative coccobacillus. The World Health Organisation receives reports of almost half a million cases each year. The most prevalent species, Brucella melitensis, is found mo [....] » Read More
Title : Evaluation of adaptive immune responses to COVID-19 vaccination in patients with comorbidities
Mayra Ashirova, South Kazakhstan Medical Academy, Kazakhstan
In Kazakhstan, the most widely utilised vaccines against the novel strain of the virus were those developed by the Russian company Gamaleya, known as Sputnik V, and by the German company BioNTech, known as Comirnaty. Elderly patients and those with comorbidities were prioritized [....] » Read More
Title : Real-world COVID-19 vaccine effectiveness in Ethiopia using a retrospective test-negative case-control study design
Gutema Bulti Tura, Ethiopian Public Health Institute, Ethiopia
Background: The Coronavirus Disease 2019 (COVID-19) pandemic has been a global health emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 vaccinations are among the significant prevention and control mechanisms. Ethiopia launched vaccinati [....] » Read More
Title : Seroprevalence of brucellosis in dairy animals and their owners in selected sites, Central Highlands of Ethiopia
Temesgen Kassa Getahun, Ethiopian Institute of Agricultural research, Ethiopia
A cross-sectional study was conducted from December, 2019 to May, 2020 with the aim to determine seroprevalence and identify the potential risk factors of brucellosis in dairy cows with recent case abortion and their owners and farm workers, and to assess knowledge, attitude an [....] » Read More
Title : Multi-marker analysis reveals an extensive genetic diversity in Rhipicephalus sanguineus (temperate lineage) and the first identification of Rhipicephalus rutilus in Tunisia
Amani, Higher Institute of Biotechnology of Sidi Thabet, Tunisia
Accurate identification of Rhipicephalus species circulating in Tunisia is essential for improving disease surveillance and implementing effective control strategies, as these ticks are key vectors of numerous pathogens affecting both animals and humans. This study aimed to evalu [....] » Read More