Acinetobacter infections, caused by the Gram-negative bacteria of the Acinetobacter genus, manifest as a growing concern in both healthcare and community settings. While Acinetobacter baumannii is the primary pathogenic species, other members of the genus can also cause infections. These bacteria are opportunistic pathogens, often affecting individuals with compromised immune systems, chronic illnesses, or those undergoing invasive medical procedures. One notable characteristic of Acinetobacter is its ability to survive in diverse environmental conditions, including on surfaces and medical equipment. This resilience contributes to the organism's persistence in healthcare settings, leading to hospital-acquired infections. The bacteria's extensive antibiotic resistance profile, including resistance to carbapenems, further complicates treatment strategies. Acinetobacter infections commonly present as pneumonia, bloodstream infections, urinary tract infections, or skin and soft tissue infections. The high mortality associated with Acinetobacter baumannii infections underscores the critical need for effective prevention and treatment strategies. Ongoing research explores alternative therapies, including phage therapy and new antimicrobial agents, to address the challenges posed by Acinetobacter infections and curb the rise of multidrug-resistant strains. Strict infection control measures, including hand hygiene and environmental cleaning, remain essential in limiting the spread of these resilient bacteria.
Title : Extensively drug-resistant bacterial infections: Confronting a global crisis with urgent solutions in prevention, surveillance, and treatment
Yazdan Mirzanejad, University of British Columbia, Canada
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Michele Mishto, Francis Crick Institute, United Kingdom
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Claudia Ferreira, Sorbonne University, France
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Pedro Plans Rubio, College of Physicians of Barcelona, Spain
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Stephanie Maltais, University of Montreal, Canada
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Stephanie Maltais, University of Montreal, Canada