While typhus fever is less common in developed regions today, it remains a concern in certain areas, especially those with poor living conditions and limited access to healthcare. Diagnosing typhus can be challenging due to its nonspecific symptoms, which can overlap with other febrile illnesses. Serological tests and polymerase chain reaction (PCR) assays are employed for confirmation, and prompt diagnosis is crucial for initiating appropriate treatment. Treatment of typhus involves the use of antibiotics, with doxycycline being a common choice. Early initiation of treatment can significantly reduce the severity and duration of the illness. However, prevention remains a cornerstone in controlling typhus outbreaks. This includes improving living conditions to minimize the proliferation of body lice, implementing vector control measures, and raising awareness about personal hygiene practices. Typhus fever, though less prevalent in the modern era, serves as a reminder of the importance of addressing social determinants of health, maintaining vigilance in regions prone to outbreaks, and investing in public health infrastructure. Ongoing research into the ecology of Rickettsia prowazekii, the dynamics of vector-borne transmission, and the development of improved diagnostics and vaccines contribute to our ability to control and mitigate the impact of typhus fever in vulnerable populations.