Claudia Ferreira, Sorbonne University, France
Bioterrorism is defined as “the intentional release or threat of release of biologic agents—viruses, bacteria, fungi, or their toxins—to cause disease or death in humans, animals, or crops.” Bioterrorism remains a significant and evolving threat to public [....] » Read More
Title : Extensively drug-resistant bacterial infections: Confronting a global crisis with urgent solutions in prevention, surveillance, and treatment
Yazdan Mirzanejad, University of British Columbia, Canada
Extensively drug-resistant (XDR) bacterial infections represent a growing global crisis with profound impacts on morbidity, mortality, and health system sustainability. These pathogens, resistant to nearly all available antibiotics, are rapidly outpacing our therapeutic options a [....] » Read More
Title : A critical assessment of dengue fever in Cambodia, Singapore, and Thailand: examining the role of social determinants in determining effectiveness and sustainability of vector control programmes
Holly Broughton, The University of Edinburgh, United Kingdom
Introduction: Dengue fever is a mosquito-borne infection which affects millions of people worldwide each year. An overwhelming majority of cases occur in Southeast (SE) Asia. Whilst many cases are asymptomatic, rising severity and mortality highlight the urgent need for effective [....] » Read More
Title : E2 ubiquitin-conjugating enzymes regulates dengue virus-2 replication in Aedes albopictus
Xueli Zheng, Southern Medical University, China
Aedes albopictus (Ae. albopictus), an important vector of dengue virus (DENV), is distributed worldwide. Identifying host proteins involved in flavivirus replication in Ae. albopictus and determining their natural antiviral mechanisms are critical to control virus transmission. R [....] » Read More
Title : Antimicrobial susceptibility of Kingella kingae isolates from Australia and New Zealand: Implications for empirical treatment of paediatric osteoarticular infections
Katharina Wolf, University of Otago, New Zealand
Kingella kingae is increasingly recognised as a leading cause of osteoarticular infections (OAI) in young children. Although generally susceptible to a broad spectrum of antibiotics, regional susceptibility data remain scarce, particularly in Australasia. In this study, we charac [....] » Read More
Title : From bench to mouse: Conjugated oligoelectrolytes potentiate frontline anti-mycobacterial antibiotics against Mycobacterium abscessus
Tania Jim, National University of Singapore, Singapore
Mycobacterium abscessus (MAB) is one of the most drug-resistant non-tuberculous mycobacteria, with multifaceted intrinsic resistance mechanisms and poor clinical outcomes. Novel therapeutic strategies are hence urgently needed. Conjugated oligoelectrolytes (COEs) are emerging [....] » Read More
Title : TLR9-dependent modulation of adipocyte differentiation by Brucella abortus DNA induces an inflammatory response
Nicole Freiberger, INBIRS-CONICET, Argentina
Brucellosis, caused by Brucella abortus (Ba), remains a neglected zoonosis with significant human morbidity, often associated with chronic inflammatory manifestations. While traditionally regarded as passive reservoirs of energy, adipocytes are now recognized as immunometabolic [....] » Read More
Title : Regulation of dikaryotic arbuscular mycorrhizal fungal infection in Vigna angularis, Vigna radiata, and Allium tuberosum by Glomus mosseae
Chihang Chang, Kang Chiao International School Linkou Campus, Taiwan
The aim of this study is to investigate whether mycorrhizal fungi infect plant species such as Vigna angularis, Vigna radiata, and Allium tuberosum to promote growth, or whether they instead contribute to disease. Existing literature highlights the complexity of these interaction [....] » Read More
Title : Regulation of dikaryotic arbuscular mycorrhizal fungal infection in Vigna angularis, Vigna radiata, & Allium tuberosum by Glomus mosseae
Lin Yucheng, Kang Chiao International School Linkou Campus, Taiwan
The aim of this study is to investigate whether mycorrhizal fungi infect plant species such as Vigna angularis, Vigna radiata, and Allium tuberosum to promote growth, or whether they instead contribute to disease. Existing literature highlights the complexity of these interaction [....] » Read More
Title : Detection and variant characterization of Lumpy Skin Disease Virus (LSDV) from dairy cattle in India
Manali Bajpai, CSIR-National Chemical Laboratory, India
The spread of a severe and often fatal form of Lumpy Skin Disease (LSD) of cattle and water buffaloes has caused widespread mortality and morbidity of these animals in India. To track and understand the genetic changes occurring in the virus and to enable routine surveillance o [....] » Read More
Title : CRISPR-based point-of-care diagnostics for real-time surveillance of FMDV and LSDV under the One Health framework
Barsha Mohanty, CrisprBits Private Limited, India
Transboundary animal diseases like Foot-and-Mouth Disease Virus (FMDV) and Lumpy Skin Disease Virus (LSDV) mostly in Cattles are significant threats to livestock health, food security, and rural livelihoods in India. Their rapid spread across species and environments highlights t [....] » Read More
Title : Immunotherapy with StroVac in the management of post-radiation cystitis and recurrent urinary infections among cervical cancer survivors
Nargiz Zeynal, NOC, Azerbaijan
Post-radiation cystitis is a common and challenging late complication among women treated for cervical cancer, frequently associated with recurrent urinary tract infections (UTIs) and reduced quality of life. Conventional antibiotic therapy often fails to provide long-term contro [....] » Read More
Title : Acceptability of mass drug administration for lymphatic filariasis in Baglung municipality of Nepal: A mixed-method study
Muskan Pudasainee, Pokhara University, Nepal
Introduction: Lymphatic filariasis (LF), a neglected tropical disease, remains a significant public health challenge in endemic regions including Baglung Municipality of Nepal. This study investigates the acceptability of mass drug administration (MDA) for LF in Baglung Municipal [....] » Read More
Title : Aerosol production associated with different respiratory manoeuvres and face coverings, and two weeks of treatment in people with tuberculosis
Zama Mahlobo, Stellenbosch University, South Africa
Background: Mycobacterium tuberculosis transmits person-to-person via aerosols. The effect of different respiratory manoeuvres and accessible yet non-conventional face coverings (paper mask, neck gaiter, bandana, and surgical masks) require clarification, as well as how thes [....] » Read More
Title : Molecular dynamics simulations reveal a novel role for procalcitonin during bacterial induced sepsis
David Young, University of Northampton, United Kingdom
Procalcitonin (PCT) is widely recognized as a key biomarker of sepsis, yet its potential role as an active modulator in a dysregulated immune response remains poorly understood. In this study, we employed all-atom molecular dynamics (MD) simulations via GROMACS to investigate a p [....] » Read More
Title : Possibilities and challenges in developing a vaccine against leishmaniasis
Rakesh Kumar Singh, Banaras Hindu University, India
A vaccine against kala-azar (visceral leishmaniasis), which is caused by the various species of a parasite that belongs to the genus Leishmania, is still an unrealized goal. The major reason behind this is the poor immunogenicity of Leishmania antigens, which do not qualify the p [....] » Read More
Title : Assessment of isoniazid preventive therapy and barriers of implementation among contacts of pulmonary tuberculosis patients in Raipur district
Ashish Sinha, Pt JNM Medical College Raipur, India
Background: For prevention, care, and control of tuberculosis, isoniazid preventive therapy (IPT) is recommended for the treatment of latent infection among contacts. Adherence to this regime is vital for obtaining good results. Objectives: To ascertain the determinants of the [....] » Read More
Title : An observational prospective study of Guillain Barre syndrome (GBS) associated with enteric infection at North India, SMS Medical College, Jaipur
Shashi Bhushan Sharma, SMS Medical College and Hospital, India
Background: Guillain-Barré Syndrome (GBS) is an acute, immune-mediated neuropathy frequently triggered by gastrointestinal or respiratory infections or vaccine induced. Among these, Campylobacter jejuni is the most widely recognized antecedent pathogen. This study aimed to [....] » Read More
Title : The therapeutic potential of IgM monoclonal antibody in a mouse model of disseminated invasive aspergillosis
Rebekah Whitehead, University of Otago, New Zealand
Invasive aspergillosis (IA) is a life-threatening disease caused primarily by Aspergillus fumigatus, followed by Aspergillus flavus, Aspergillus terreus and Aspergillus niger. Despite the advances in antifungal therapies, IA remains associated with a high morbidity and mortality, [....] » Read More
Title : Rapid identification of Bacillus anthracis biomarkers via mass spectrometry: A review and its implications for biodefense
Jacqueline Roberta Soares Salgado, Engineering Military Institute (IME) of the Brazilian Army, Brazil
The rapid and unequivocal identification of pathogenic biological agents is a pivotal cornerstone in biodefense and chemical defense, particularly in light of the persistent threat of bioterrorism. Bioterrorism poses a significant global hazard, with Bacillus anthracis, the Abstr [....] » Read More
Title : Diverse clinical presentations of brucellosis in a tertiary care centre
Ujwal Ramrao Shinde, Bharati Vidyapeeth Deemed University, India
Brucellosis, an endemic zoonosis in many countries, is caused by bacteria of the genus Brucella, a Gram-negative coccobacillus. The World Health Organisation receives reports of almost half a million cases each year. The most prevalent species, Brucella melitensis, is found mo [....] » Read More
Title : The impact of antibiotic growth promoters on broiler chicken and environmental health in Kibaha Town Council – Tanzania
Damas Theobald Msaki, Kibaha Education Centre, Tanzania, United Republic of
Introduction: A cross-sectional survey was conducted at Kibaha Town (Tanzania) to assess awareness and effects of using antibiotic growth promoters (AGPs) on both broiler chicken and environmental health. Objectives: This study aimed at investigating the effects of using antib [....] » Read More
Title : Real-world COVID-19 vaccine effectiveness in Ethiopia using a retrospective test-negative case-control study design
Gutema Bulti Tura, Ethiopian Public Health Institute, Ethiopia
Background: The Coronavirus Disease 2019 (COVID-19) pandemic has been a global health emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 vaccinations are among the significant prevention and control mechanisms. Ethiopia launched vaccinati [....] » Read More
Title : Seroprevalence of brucellosis in dairy animals and their owners in selected sites, Central Highlands of Ethiopia
Temesgen Kassa Getahun, Ethiopian Institute of Agricultural Research, Ethiopia
A cross-sectional study was conducted from December, 2019 to May, 2020 with the aim to determine seroprevalence and identify the potential risk factors of brucellosis in dairy cows with recent case abortion and their owners and farm workers, and to assess knowledge, attitude an [....] » Read More
Title : Duration of antibiotic therapy in intensive care
Sawssen Tihamy, University Hospital Center Ibn Rochd ICU 33, Morocco
Introduction: Antibiotics are the most widely prescribed drugs. Despite their many benefits, inappropriate use is not without risks. It is associated with the emergence of multidrug-resistant organisms, harmful effects on patients, and increased healthcare costs. As part of th [....] » Read More
Title : Multi-marker analysis reveals an extensive genetic diversity in Rhipicephalus sanguineus (temperate lineage) and the first identification of Rhipicephalus rutilus in Tunisia
Amani, Higher Institute of Biotechnology of Sidi Thabet, Tunisia
Accurate identification of Rhipicephalus species circulating in Tunisia is essential for improving disease surveillance and implementing effective control strategies, as these ticks are key vectors of numerous pathogens affecting both animals and humans. This study aimed to evalu [....] » Read More
Title : The combination (amphotericin B + EDTA) as an antifungal blocking agent in the inhibition of mixed biofilm formation on catheters
Ziane, University of Tlemcen, Algeria
Introduction: Vascular and urinary catheterization are routine procedures in hospitals, exposing patients to the risk of infection, the pathophysiology of which is closely linked to the presence of microorganisms on these implants. The ability to form biofilms is considered an im [....] » Read More
Title : Subtractive proteomics and immunoinformatics based design of a chimeric antigen for Leishmania aethiopica to diagnose cutaneous leishmaniasis
Deborah Telahun Teka, Bio and Emerging Technology Insitute, Ethiopia
Leishmania aethiopica is a protozoan parasite that is the main causative agent of cutaneous leishmaniasis (CL), a debilitating skin disease in Ethiopia. Currently, there are no L. aethiopica targeting immunodiagnostics on the market. This study identified candidate proteins of L. [....] » Read More